教育部新世纪优秀人才, 福建省新世纪优秀人才

个人简介

博士: 天津大学, 2003; 硕士: 天津大学, 2001; 学士:吉林化工学院, 1994.

http://cm.xmu.edu.cn/s/35/t/123/2e/fc/info77564.htm

电子邮箱: shiwei@xmu.edu.cn

研究方向

智能药物释放体系

生物材料

膜式人工器官

生物传感器

近期亮点

光敏剂的聚集是制约光动力治疗效率的主要问题之一。我们利用介孔SiO2的介孔空间装载光敏剂，并通过PEI和PEG修饰获得了多功能化的光敏剂载药体系。该体系能有效防止光敏剂的聚集，并能逃逸溶酶体于胞浆释放，显著提高了光动力治疗的效率。（Biomaterials, 2012,33: 7903-7914）

代表著作

J. Wang, G.S. Wu, W. Shi*, X. Liu, C.Q. Ruan, M.Q. Xue, D.T. Ge, Affinity electromembrane with covalently coupled heparin for thrombin adsorption, Journal of Membrane Science, 2013, 428: 70–77

F.Q. Meng, W. Shi*, Y.N. Sun, X. Zhu, G.S. Wu, C.Q. Ruan, X. Liu, D.T. Ge, Nonenzymatic biosensor based on CuxO nanoparticles deposited on polypyrrole nanowires for improving detection range”, Biosensors and Bioelectronics, 2013, 42: 141–147

J. Tu, T.X. Wang, W. Shi*, G.S. Wu, X.H. Tian, Y.H. Wang, D.T. Ge, L. Ren*, Multifunctional ZnPc-loaded mesoporous silica nanoparticles for enhancement of photodynamic therapy efficacy by endolysosomal escape, Biomaterials, 2012, 33: 7903–7914.

J. Wang, W. Shi*, H.R. Jiang, G.S. Wu, C.Q. Ruan, D.T. Ge, Heparin-doped affinity electromembranes for thrombin purification, Journal of Membrane Science, 2011, 373: 89–97.

C.F. Song, W. Shi*, H.R. Jiang, J. Tu, D.T. Ge, pH-sensitive characteristics of poly(acrylic acid)-functionalized anodic aluminum oxide (AAO) membranes, Journal of Membrane Science, 2011, 372: 340–345.

W. Shi*, Y.Y. Ma, C.F. Song, H.R. Jiang, X.N. Ru, J. Tu, S.H. Jiang, J. Wang, D.T. Ge, Affinity electromembrane: electrically facilitated adsorption, Journal of Membrane Science, 2010, 354: 86–92

W. Shi*, H.H. Cao, C.F. Song, H.R. Jiang, J. Wang, S.H. Jiang, J. Tu, D.T. Ge, Poly(pyrrole-3-carboxylic acid)–alumina composite membrane for affinity adsorption of bilirubin, Journal of Membrane Science, 2010, 353: 151–158.

W. Shi*, Y.Q. Shen, H.R. Jiang, C.F. Song, Y.Y. Ma, J. Mu, B.Y. Yang, D.T. Ge, Lysine-attached anodic aluminum oxide (AAO)–silica affinity membrane for bilirubin removal, Journal of Membrane Science, 2010, 349: 333–340.

D.T. Ge, D.W. Wu, Z.Y. Wang, W. Shi*, T. Wu, A.F. Zhang, S.M. Hong, J. Wang, Y. Zhang, L. Ren*, Cellular uptake mechanism of molecular umbrella, Bioconjugate Chemistry, 2009, 20: 2311–2316.

W. Shi*, Q.Y. Shen, D.T. Ge, M.Q. Xue, H.H. Cao, S.Q. Huang, J.X. Wang, G.L. Zhang, F.B. Zhang, Functionalized anodic aluminum oxide (AAO) membranes for affinity protein separation, Journal of Membrane Science, 2008, 325: 801–808.