•优秀本科生导师，2007，厦门大学

•济宁市科技进步三等奖，1998

•指导的团队，2006年在第五届“恒安杯”厦门大学创业竞赛和第四届“挑战杯”福建省大学生创业计划竞赛中夺得一等奖和唯一的“最佳团队奖”及“金奖”

研究方向

近期亮点

抗肿瘤药物甲胺喋砱是双功能分子既是药物又是靶向分子，最近研究认为其靶向分子与叶酸相近。利用聚乙二醇修饰的壳聚糖纳米粒子分别用甲胺喋砱和叶酸修饰，利用活体荧光，激光共聚焦和流式细胞实验首次证明其靶向性比叶酸要强1.7倍左右，为设计双载药靶向抗肿瘤药物传输系统成为可能。

代表著作

1. Hou Zhenqing, Zhang Zhenxi, Zhang Chuanxin, et al. Use of natural plant exudates (Sanguis Draxonis) for sustained oral insulin delivery with dramatic reduction of glycemic effects in diabetic rats, Journal of Controlled Release, 2004, 97(3):467-475.

2. Zhenqing Hou, Heng Wei, Qian Wang, Chunxiao Zhou, Chuanming Zhan, Xiaolong Tang, Qiqing Zhang, New method to prepar mitomycin C loaded PLA- nanoparticles with high drug entrapment efficiency, Nanoscale Res Lett. 2009, 4: 732-737

3. Zhenqing Hou, Qian Sun, Qian Wang, Jing Han, Yuqian Wang, Qiqing Zhang* In vitro and in vivo evaluation of novel implantable collagen-chitosan soybean phosphatidylcholine composite film for sustained delivery of mitomycin C，Drug Development Research, 2009, 700: 206-213

4. Zhenqing Hou, Jing Han, Chuanming Zhan, Chunxiao Zhou, Qiqing Zhang, Synthesis and evaluation of N-succinyl-chitosan nanoparticles toward local hydroxycamptothecin delivery, Carbohydrate Polymers, 2010,81:765-768

5. Hou ZQ, Zhan CM, Zhu PJ, Li L, Chang D, Jiang QW, Ye SF, Yang XR, Li Yang, Xie LY, Zhang QQ. Preparation and in vitro evaluation of an ultrasound-triggered drug delivery system: 10-hydroxycamptothecin loaded PLA microbubbles, Ultrasonics, 2012, 52(7):836-841.

6. Zhenqing Hou, Chunxiao Zhou, Ying Luo, Chuanming Zhan, Yixiao Wang, Liya Xie, Qiqing Zhang, PLA nanoparticles loaded with an active lactone form of hydroxycamptothecin: Development, optimization and in vitro-in vivo evaluation in mice bearing H22 solid tumor, Drug Development Research, 2011, 72:1-9.

7. Zhengqing Hou，Chuanming Zhan, Qiwei Jiang, Quan Hu, Le Li, Di Chang, Xiangrui Yang, Yixiao Wang, Yang Li, Shefang Ye, Liya Xie, Yunfeng Yi and Qiqing Zhang. Both FA and mPEG conjugated chitosan nanoparticles for targeted cellular uptake and enhanced tumor tissue distribution. Nanoscale Reseach Letters, 2011, 6(1):563

8. Zhenqing Hou, Yang Li, Yuancan Huang, Chunxiao Zhou, Jinyan Lin, Yixiao Wang, Fei Cui, Shuifan Zhou, Mengmeng Jia, Shefang Ye, Qiqing Zhang, Phytosomes loaded with mitomycin C-soybean phosphatidylcholine complex developed for drug delivery. Mol. Pharmoceutics, 2013, 10:90-101