The Ministry of education in the new century excellent talents, New Century Excellent Talents in Fujian Province

Personal profile

Doctor: Tianjin University, 2003; Tianjin University, 2001; bachelor master:: Jilin Institute of Chemical Technology, 1994

Http://cm.xmu.edu.cn/s/35/t/123/2e/fc/info77564.htm

E-mail: shiwei@xmu.edu.cn

Research direction

Intelligent drug delivery system

Biological materials

Membrane type artificial organs

The biosensor

Recent bright spots

Photosensitizer aggregation is one of the main problems to restrict the efficiency ofphotodynamic therapy. We use the pore space of mesoporous SiO2 loadingphotosensitizer, and through PEI and PEG modified the multifunctionalphotosensitizer drug carrier system. The system can effectively prevent thephotosensitizer aggregation, and able to escape the lysosome release in the cytoplasm, significantly improve the efficiency of photodynamic therapy.(Biomaterials, 2012,33: 7903-7914)

The representative works

J. Wang, G.S. Wu, W. Shi*, X. Liu, C.Q. Ruan, M.Q. Xue, D.T. Ge, Affinity electromembrane with covalently coupled heparin for thrombin adsorption, Journal of Membrane Science, 2013, 428: 70–77

F.Q. Meng, W. Shi*, Y.N. Sun, X. Zhu, G.S. Wu, C.Q. Ruan, X. Liu, D.T. Ge, Nonenzymatic biosensor based on CuxO nanoparticles deposited on polypyrrole nanowires for improving detection range”, Biosensors and Bioelectronics, 2013, 42: 141–147

J. Tu, T.X. Wang, W. Shi*, G.S. Wu, X.H. Tian, Y.H. Wang, D.T. Ge, L. Ren*, Multifunctional ZnPc-loaded mesoporous silica nanoparticles for enhancement of photodynamic therapy efficacy by endolysosomal escape, Biomaterials, 2012, 33: 7903–7914.

J. Wang, W. Shi*, H.R. Jiang, G.S. Wu, C.Q. Ruan, D.T. Ge, Heparin-doped affinity electromembranes for thrombin purification, Journal of Membrane Science, 2011, 373: 89–97.

C.F. Song, W. Shi*, H.R. Jiang, J. Tu, D.T. Ge, pH-sensitive characteristics of poly(acrylic acid)-functionalized anodic aluminum oxide (AAO) membranes, Journal of Membrane Science, 2011, 372: 340–345.

W. Shi*, Y.Y. Ma, C.F. Song, H.R. Jiang, X.N. Ru, J. Tu, S.H. Jiang, J. Wang, D.T. Ge, Affinity electromembrane: electrically facilitated adsorption, Journal of Membrane Science, 2010, 354: 86–92

W. Shi*, H.H. Cao, C.F. Song, H.R. Jiang, J. Wang, S.H. Jiang, J. Tu, D.T. Ge, Poly(pyrrole-3-carboxylic acid)–alumina composite membrane for affinity adsorption of bilirubin, Journal of Membrane Science, 2010, 353: 151–158.

W. Shi*, Y.Q. Shen, H.R. Jiang, C.F. Song, Y.Y. Ma, J. Mu, B.Y. Yang, D.T. Ge, Lysine-attached anodic aluminum oxide (AAO)–silica affinity membrane for bilirubin removal, Journal of Membrane Science, 2010, 349: 333–340.

D.T. Ge, D.W. Wu, Z.Y. Wang, W. Shi*, T. Wu, A.F. Zhang, S.M. Hong, J. Wang, Y. Zhang, L. Ren*, Cellular uptake mechanism of molecular umbrella, Bioconjugate Chemistry, 2009, 20: 2311–2316.

W. Shi*, Q.Y. Shen, D.T. Ge, M.Q. Xue, H.H. Cao, S.Q. Huang, J.X. Wang, G.L. Zhang, F.B. Zhang, Functionalized anodic aluminum oxide (AAO) membranes for affinity protein separation, Journal of Membrane Science, 2008, 325: 801–808.