Recent bright spots

Anti tumor drug methotrexate, Ling is a bifunctional molecule is not only a drug istargeting molecules, recent studies indicate that the target molecule and folic acidare similar. With methotrexate, Ling and folic acid chitosan nanoparticles modifiedby polyethylene glycol modified, using in vivo fluorescence, confocal microscopy and flow cytometry experiments demonstrate for the first time the target about 1.7 times stronger than folic acid, may be to design dual drug carrier targeting antitumordrug delivery system.

The representative works

1. Hou Zhenqing, Zhang Zhenxi, Zhang Chuanxin, et al. Use of natural plant exudates (Sanguis Draxonis) for sustained oral insulin delivery with dramatic reduction of glycemic effects in diabetic rats, Journal of Controlled Release, 2004, 97(3):467-475.

2. Zhenqing Hou, Heng Wei, Qian Wang, Chunxiao Zhou, Chuanming Zhan, Xiaolong Tang, Qiqing Zhang, New method to prepar mitomycin C loaded PLA- nanoparticles with high drug entrapment efficiency, Nanoscale Res Lett. 2009, 4: 732-737

3. Zhenqing Hou, Qian Sun, Qian Wang, Jing Han, Yuqian Wang, Qiqing Zhang* In vitro and in vivo evaluation of novel implantable collagen-chitosan soybean phosphatidylcholine composite film for sustained delivery of mitomycin C，Drug Development Research, 2009, 700: 206-213

4. Zhenqing Hou, Jing Han, Chuanming Zhan, Chunxiao Zhou, Qiqing Zhang, Synthesis and evaluation of N-succinyl-chitosan nanoparticles toward local hydroxycamptothecin delivery, Carbohydrate Polymers, 2010,81:765-768

5. Hou ZQ, Zhan CM, Zhu PJ, Li L, Chang D, Jiang QW, Ye SF, Yang XR, Li Yang, Xie LY, Zhang QQ. Preparation and in vitro evaluation of an ultrasound-triggered drug delivery system: 10-hydroxycamptothecin loaded PLA microbubbles, Ultrasonics, 2012, 52(7):836-841.

6. Zhenqing Hou, Chunxiao Zhou, Ying Luo, Chuanming Zhan, Yixiao Wang, Liya Xie, Qiqing Zhang, PLA nanoparticles loaded with an active lactone form of hydroxycamptothecin: Development, optimization and in vitro-in vivo evaluation in mice bearing H22 solid tumor, Drug Development Research, 2011, 72:1-9.

7. Zhengqing Hou，Chuanming Zhan, Qiwei Jiang, Quan Hu, Le Li, Di Chang, Xiangrui Yang, Yixiao Wang, Yang Li, Shefang Ye, Liya Xie, Yunfeng Yi and Qiqing Zhang. Both FA and mPEG conjugated chitosan nanoparticles for targeted cellular uptake and enhanced tumor tissue distribution. Nanoscale Reseach Letters, 2011, 6(1):563

8. Zhenqing Hou, Yang Li, Yuancan Huang, Chunxiao Zhou, Jinyan Lin, Yixiao Wang, Fei Cui, Shuifan Zhou, Mengmeng Jia, Shefang Ye, Qiqing Zhang, Phytosomes loaded with mitomycin C-soybean phosphatidylcholine complex developed for drug delivery. Mol. Pharmoceutics, 2013, 10:90-101